Endocrine Abstracts

Thyrotoxic periodic paralysis (TPP) is a rare endocrine emergency where early diagnosis of both hypokalaemia and thyrotoxicosis are vital to allow prompt treatment to prevent life-threatening complications and prevent recurrences. We present the first reported case of TPP in which four known stimulants of Na–K–ATPase acted simultaneously to produce profound hypokalaemia. A 32 year-old competitive body-builder took thyroxine supplements & a long-acting β2 ago...

Obesity is often framed as a consequence of inadequate physical activity, and patients with severe obesity sometimes attribute their weight gain to immobility and reduced exercise. We sought to compare Total Daily Energy Expenditure (TDEE) in adults with severe obesity to what their predicted TDEE would be at their Ideal Body Weight (IBW). We conducted a cross-sectional analysis of the Croí CLANN prospective cohort study of patients with severe obesity attending our regio...

Introduction: Skin tags (acrochordons) are a recognised feature of insulin resistance, but the extent to which they predict an adverse metabolic profile or the response to lifestyle modification in severely obese adults is not known.Aims: We sought to quantify prospectively differences in anthropometric and metabolic characteristics in severely obese adults with acrochordons vs those without acrochordons, and to determine whether the presence of acrochor...

Background: Predictions estimate that the majority of the global population will be living with overweight and obesity by 2035. Due to its widespread use and ability to disseminate information, social media has a potentially prominent role in obesity care and education. Regulatory bodies issue ethical guidance on social media use. However, it is unknown how healthcare professionals’ (HCP) online activity affects people living with obesity. By exploring th...

Therapeutic options for patients with severe obesity are limited. Low energy meal replacement regimes can induce significant short-term weight loss and improvements in metabolic variables. We sought to estimate the effect size on adiposity and cardiovascular risk factors of a relatively inexpensive 24-week regime based on meal replacement with semi-skimmed milk in severely obese adults. A retrospective cohort analysis showed that of 206 patients in our hospital-based bariatric...

Background: Lifestyle modification is fundamental to obesity treatment, but few studies have described the effects of structured lifestyle programmes specifically in bariatric patients. We sought to describe changes in anthropometric and metabolic characteristics in a cohort of bariatric patients after participation in a nurse-led, structured lifestyle programme.Methods: We conducted a retrospective, observational cohort study of adults with a BMI ≧40...

Background: Bariatric surgery is known to dramatically increase insulin sensitivity in severely obese adults. However quantifying insulin sensitivity in these patients with methods such as the hyperinsulinaemic euglycaemic clamp is technically challenging. The leptin to adiponectin ratio (LAR) has previously been validated as a measure of whole body insulin sensitivity. Leptin is a known mediator of metabolic and cardiovascular complications of obesity. Adiponectin has anti-at...

BackgroundStructured lifestyle modification programmes are offered as first line treatment to patients referred to bariatric specialist services. We sought to describe changes in anthropometric and metabolic characteristics in a cohort of bariatric patients following completion of an eight-week, multidisciplinary group-based lifestyle intervention focussed on diet and physical activity.MethodsWe conducted a p...